Revolutionary nanodrones enable targeted cancer treatment

Revolutionary nanodrones enable targeted cancer treatment

technology By Dec 29, 2023 No Comments

Revolutionary Nanodrones for Targeted cancer treatment: A Breakthrough in Cancer Therapy

In a pioneering study led by Professor Sebyung Kang and Professor Sung Ho Park in the Department of Biological Sciences at UNIST, a groundbreaking advancement in cancer treatment has been unveiled. The research team’s development of “NK cell-engaging nanodrones” marks a significant step forward in the targeted treatment of cancer.

The Significance of NK Cell-Engaging Nanodrones

The research team at UNIST has successfully created innovative “NK cell-engaging nanodrones,” a revolutionary concept in cancer treatment. These nanodrones have the potential to selectively target and eliminate specific cancer cells, offering hope for treating previously difficult-to-treat cancers.

Nanodrones Unveiled: A Deep Dive into the research

Utilizing cutting-edge technology, the team has designed and fabricated exceptional NK cell-engaging nanodrones, referred to as NKeNDs. These nanodrones simultaneously display cancer-targeting and NK cell-recruiting ligands, offering a dual mechanism for effectively targeting and eliminating cancer cells.

By employing protein cage nanoparticles, the research has pioneered a novel approach to developing cancer-specific NK cell engagers. The dual ligand-displaying NKeNDs, named HER2 @NKeND and EGFR@NKeND, have demonstrated an unparalleled ability to bind to specific cancer cells, as well as human NK cells, heralding a new era in cancer treatment.

Highlighting the Efficacy of Nanodrones in cancer treatment

A pivotal breakthrough in cancer therapy, the use of NK cell-engaging nanodrones has showcased a remarkable ability to recruit NK cells to target tumor sites and effectively suppress tumor growth. In preclinical studies involving tumor-bearing mice, the administration of HER2 @NKeNDs has led to significant suppression of tumor growth without noticeable side effects.

The physical engagement of human NK cells with the target cancer cells mediated by the NKeNDs has activated the NK cells, enabling them to eliminate the target cancer cells effectively. Moreover, the study has provided valuable insights into the movement and survival of NK cells, overcoming significant challenges in immune treatment for cancer.

Future Implications and Potential Applications

Professor Kang Se-byung expressed excitement about the study’s implications, stating, “This research presents new possibilities for immune treatment through NK cell delivery nanodrones, overcoming challenges such as the movement and survival of NK cells. This pioneering approach offers tremendous potential for the selective treatment of previously intractable types of cancers.”

Conclusion: A Revolution in cancer treatment

The unveiling of NK cell-engaging nanodrones marks a significant step forward in the targeted treatment of cancer. The promising results from preclinical studies demonstrate the potential for this innovative approach to transform cancer therapy. As researchers continue to explore the applications of nanodrones in cancer treatment, the future holds immense promise for personalized and targeted treatments.

Source: phys

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